Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level
https://pubs.acs.org/doi/10.1021/acsami.0c21002
MEDIA TAKES TO THE STREETS TO PROVE OR DISPROVE THAT MAGNETS STICK TO INJECTION SITES
LAGUNA BEACH - About half confirm magnets are sticking. Their assumption is they've been microchipped, however it may be more sinister than that.
Back in 2016, researchers were celebrating what they called a “badass” new method of remotely controling brain and behaviour using a magnetised protein.
This genetically engineered ‘Magneto’ protein, or 'Magneto DNA sequence' is inserted into the genome of a virus, together with a gene encoding fluorescent protein (likely luciferase (https://www.moleculardevices.com/sites/default/files/en/assets/newsletter/november-2020.html#gref)), and regulatory DNA sequences.
They can be genetically engineered so that they become sensitive to radio waves and magnetic fields, by attaching them to an iron-storing protein called ferritin, or to inorganic paramagnetic particles. Application of a magnetic field activates the engineered protein. These stimuli evokes nervous impulses that travel into the spinal cord and then up to the brain. Read more here: [ Read the Article (https://www.theguardian.com/science/neurophilosophy/2016/mar/24/magneto-remotely-controls-brain-and-behaviour) | Archive (https://archive.is/OfY0g) ]
Study: Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level | March 2021
https://pubs.acs.org/doi/10.1021/acsami.0c21002
pubs.acs.org (https://pubs.acs.org/doi/10.1021/acsami.0c21002)
Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level
Remote control of cells and single molecules by magnetic nanoparticles in nonheating external magnetic fields is a perspective approach for many applications such as cancer treatment and enzyme activity regulation. However, the possibility and mechanisms of direct effects of small individual magnetic nanoparticles on such processes in magneto-mechanical experiments still remain unclear. In this work, we have shown remote-controlled mechanical dissociation of short DNA duplexes (18–60 bp) under the influence of nonheating low-frequency alternating magnetic fields using individual 11 nm magnetic nanoparticles. The developed technique allows (1) simultaneous manipulation of millions of individual DNA molecules and (2) evaluation of energies of intermolecular interactions in short DNA duplexes or in other molecules. Finally, we have shown that DNA duplexes dissociation is mediated by mechanical stress and produced by the movement of magnetic nanoparticles in magnetic fields, but not by local overheating. The presented…
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